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- Pseudomonas aeruginosa video (large) [MP4 format, 14Mb]
- Pseudomonas aeruginosa video (very low quality) [MP4 format, 2Mb]
Pseudomonas aeruginosa causes 30% of respiratory infections.
Pseudomonas aeruginosa is an opportunistic pathogen that commonly infects immunocompromised hosts.
Pseudomonas aeruginosa has a single polar flagellum which aids in motility and multiple Type IV pili. Both enhance pathogenicity of this organism.
Physical contact with the host epithelial cells induces virulence gene expression in P. aeruginosa.
Bacterial cells attach to the host cell via pili.
Cell surface attachment stimulates polymerization of the Type III Secretion needle complex.
Through this needle complex cytotoxins are injected into the host cell.
Actin cytoskeleton integrity of the host cell is disrupted. Cell membrane ruffling occurs.
Cell death ensues.