Marion Peters, M.D.

Professor of Medicine
John V. Carbone, M.D., Endowed Chair in Medicine
Chief of Hepatology Research

Academic Office and Laboratory
Division of Gastroenterology
513 Parnassus Avenue, Room S-357
San Francisco, CA 94143-0358
Phone: 415-476-2777
Fax: 415-476-0659
Email: marion.peters@ucsf.edu

Clinic
UCSF GI Faculty Practice
350 Parnassus Avenue, Suite 410
San Francisco, CA 94143-0657
Phone: 415-353-2318
Fax: 415-353-2407

Active Projects:
Translational:

Host-viral interactions in Hepatitis C and Hepatitis B infection. These projects evaluate clinical outcomes and the role of inflammatory cytokines and their receptors using DNA polymorphism analysis and mRNA gene profiling. We will assess the effect of the host response in induction of disease and response to therapy including the effect of alcohol and HIV co-infection

Clinical:

Clinical studies in the role of alcohol in Hepatitis C infection
Co-infection of HIV patients with Hepatitis B and C
The role of liver disease in HIV infection

These studies evaluate outcome and response to therapy.

Techniques in Use:

Laboratory studies: molecular techniques including DNA preparation; analysis of gene expression at the protein and mRNA level; cell culture techniques of human mononuclear cells including cell isolation, cytokine and immune functional analyses; cellular immunology techniques.
Clinical studies: Design of clinical studies, data /statistical analyses and manuscript preparation.

EDUCATION
1966-72	M.B.B.S. Melbourne University Medical School, Melbourne University, Australia
1969-72	St. Vincent's Hospital, Melbourne, Australia

Graduate
1991	M.D. Thesis, University of Melbourne, Australia. "Human B cell function and the role of Cytokines"

TRAINING
1973-76	Resident and Registrar in Internal Medicine, St.Vincent's Hospital, Melbourne, Australia
1976-77	Clinical Research Registrar to Dr. I. R. Mackay, Royal Melbourne Hospital and The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
1977-78	Gastroenterology Registrar, St. Vincent's Hospital, Melbourne, Australia
1978-80	Clinical Research Fellow in Hepatology to Dr. T. B. Reynolds, University of Southern California, Los Angeles, CA
1980-83	Visiting Fogarty Fellow to Dr. A.S. Fauci, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, NIH, Bethesda, MD
1983-85	Visiting Staff Fellow to Liver Diseases Section, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD

CERTIFICATION
1972	E.C.F.M.G.
1978	Visa Qualifying Examination (VQE)
1979	FLEX
1979	F.R.A.C.P. Royal Australasian College of Physicians: Board certified in Gastroenterology and Internal Medicine, Australia
198l	Certified Endoscopist in Gastroenterology (Australia)
1984	Diplomate American Board of Internal Medicine

MEMBERSHIPS AND AFFILIATIONS

1979-present

Royal Australasian College of Physicians

American Association for the Study of Liver Disease
1990-92	Membership Committee
1990-95, 98	Abstract Selection Committee
1991	Nominating Committee
1991-1994	Program Evaluation Committee
1994-97	Councillor-at-large, first woman on Governing Board
1997-2000	Task Force Chair: Strategic Alliance
2000	Partnership Task Force AASLD/ALF
2003-2004	Training and Workforce Committee
2004	Co-Chair Autoimmune Hepatitis Focused Study group
2004-2006	Chair review section on "HCV- Therapy- Preclinical and Early Clinical Development"
2004	Moderator Early Morning Workshop: Pathogenesis of Autoimmune Hepatitis
2005	Course Director: Postgraduate Course: "Acute and Chronic liver disease: Immunologic Mechanisms and Therapy"
2006	Co-Chair HIV and Hepatotoxicity Focused Study group

American Association of Immunologists (AAI) member since 1985
1994- 1997	Program Committee AAI

American Gastroenterological Society
1995	Co-Chair Postgraduate Course
1996-2005	Mentor in Career Development Program
2001-2004	Women in Gastroenterology committee
2004-2005	Nominating Committee

American Digestive Health Foundation
1996-1997	Board of Directors- member
1997	Nominating Committee member

American Liver Foundation
1998	Hepatitis B Symposium: organizing Committee
2001-present	Medical Advisory Board, member
2004-present	ALF Grants Review Committee Member
2005-2007	Chair of Medical Advisory Board, Northern California Chapter

AIDS Clinical Trial Group
1999-2003	Complications Research Agenda Committee member
1999-2000	Viral Hepatitis Focus Group and Liver Diseases Focus group: Co-Chair
1999- 2006	Team member of A5071- Hepatitis C and HIV therapy with Interferon and ribavirin
2000-2001	Liver Diseases Subcommittee focus group Co-Chair
2000-2002	Liver Diseases Subcommittee Chair
2003	Liver Diseases Subcommitte Member
2000-2006	Cochair of A5127: Hepatitis B and HIV therapy with adefovir versus tenofovir
2002-2003	Member Genomics Group Complications Research Agenda Committee
2003	Member Hepatitis Advisory Board
2003	Chair: Cross Research Agenda Committees: HCV Working Group
2003	Chair: Hepatitis Advisory Committee
2004-2007	Chair Hepatitis Research Agenda Committee
2007-present	Hepatitis Committee Member
2003-2007	Member Scientific Agenda Steering Committee
2004-2007	Member Cross Research Agenda Committee
2004-2006	Team member A5204
2003-	Team member A5220

National Institutes of Health
2001	Ad Hoc Reviewer, NIAAA
2002	Member, Working group Hepatitis C and Alcohol
2001	Consensus Conference Hepatitis C, speaker
2004	Ad hoc reviewer for T 32 grants
2004-present	Action Plan for HIV and Liver disease, member, NIDDK
2006	Ad hoc reviewer NIAAA, ACE study section

International Workshop on HIV and Hepatitis Co-infection
2004-present	Scientific Committee member
2005-present	Organizing committee member
2006-2008	Chair, organizing committee

Women's Interagency HIV Study (WIHS)
2005-present	Chair, Viral hepatitis working group
2007	DHHS-IDSA: member of committee for Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults

University College Dublin
2006-2008	External Examiner for Final year medical students

Penang Medical College, Malaysia
2007-	External Examiner for Final year medical students

SELECTED PUBLICATIONS

Peters MG, Andersen J, Lynch P, Liu T, Alston-Smith B, Brosgart CL, Jacobson JM, Johnson VA, Pollard RB, Rooney JF, Sherman KE, Swindells S, Polsky B; ACTG Protocol A5127 Team. Randomized controlled study of tenofovir and adefovir in chronic hepatitis B virus and HIV infection: ACTG A5127. Hepatology. 2006 Nov;44(5):1110-6.
James Buxbaum, Peiqing Qian, Ciera Khuu, Benjamin L. Shneider, David I. Daikh, ,Paul M. Allen, and Marion G. Peters. Novel Model of antigen specific induction of bile duct injury. Gastroenterology Gastroenterology. 2006 131:1899-906.
Marion G. Peters, Adrian M. Di Bisceglie, Kris V. Kowdley, Nancy L. Flye, Scott S. Emerson, Velimir A Luketic, Santiago J. Munoz, Guadalupe Garcia-Tsao, Kent G. Benner, Thomas D. Boyer, John R. Lake, Rowen K. Zetterman, Robert L. Carithers, Jr., Maurizio Bonacini, David S. Barnes and Burton Combes for the PUMPS Study Group. Differences between Caucasian, African-American and Hispanic patients with Primary Biliary Cirrhosis in USA. Hepatology: 2007; 46; 769-775.
Julie H. Ishida, Marion G. Peters, Chengshi Jin, Karly Louie, Vivian Tan, Peter Bacchetti, Norah A. Terrault. Influence of Cannabis Use on Severity of Hepatitis C Disease. Clin Gastroenterol Hepatol 2008:6(1):69-75
James Buxbaum, Peiqing Qian, Paul M. Allen, and Marion G. Peters. Hepatitis resulting from liver-specific expression and recognition of self-antigen. J Autoimmunity in press 2008
Margaret Koziel and Marion Peters. Viral Hepatitis in HIV Infection. New Eng J Med, 2007: 356; 1445-54.
Oren K Fix and Marion Peters Hepatitis virus infections, in Global HIV/AIDS Medicine Editors: Sande, Volberding & Lange, 2007; 37; 415-423.
David J. Quan and Marion G. Peters. Tenofovir disoproxil fumarate for the treatment of hepatitis B virus infection: pharmacokinetics and clinical efficacy. Therapy 2007; 4; 141-151.
Marion Peters. Hepatobiliary Complications. American Academy of HIV Medicine Study Guide, Fundamentals of HIV Medicine 2007. John Stansell Editor. In press 2008.
Oren K Fix, Stephen A. Locarnini and Marion G. Peters. Virology and clinical management of Heptitis B and HIV co-infection. PRN notebook 2007 in press
Kenneth E. Sherman, , Marion Peters, Margaret J. Koziel, . HIV and Liver Disease Forum: Conference Proceedings. Hepatology 2007: 45(6):1566-77
George Lau, Patrick Marcellin and Marion Peters. Chronic hepatitis B – a global health problem requiring coherent worldwide treatment strategies. Hepatology International In press 2007.
Marion Peters: HIV and Hepatitis B Virus Coinfection, Top HIV Med. 2007;15:163-6.
Choi G and Peters M. The Challenge of Diagnosing Autoimmune Hepatitis: less is more. Editorial Hepatology 2008 in press
Peters MG. Special populations with hepatitis B virus infection. Hepatology. 2009 May;49(5 Suppl):S146-55.
Peters MG. End-stage liver disease in HIV disease. Top HIV Med. 2009 Sep-Oct;17(4):124-8.
Peters MG, Perrillo RP, Jacobson IM, Ross DB, Doo EC, Murray JS, Wong JB. Entering the new era of therapy for HBV and HCV infections. J Fam Pract. 2010 Apr;59(4 Suppl):S51-8.
Peters MG, Weinbaum C, Tan L, Baine WB, Dienstag JL, Liang TJ, So S. Recommendations for prevention, screening, and diagnosis of HBV and HCV infections. J Fam Pract. 2010 Apr;59(4 Suppl):S29-35.
Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL, Thio CL. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. J Infect Dis. 2010 May 1;201(9):1371-80.
Kuniholm MH, Kovacs A, Gao X, Xue X, Marti D, Thio CL, Peters MG, Terrault NA, et al. Specific human leukocyte antigen class I and II alleles associated with hepatitis C virus viremia. Hepatology. 2010 May;51(5):1514-22.
Overton ET, Kang M, Peters MG, Umbleja T, Alston-Smith BL, Bastow B, Demarco-Shaw D, Koziel MJ, Mong-Kryspin L, Sprenger HL, Yu JY, Aberg JA. Immune response to hepatitis B vaccine in HIV-infected subjects using granulocyte-macrophage colony-stimulating factor (GM-CSF) as a vaccine adjuvant: ACTG study 5220. Vaccine. 2010 Aug 2;28(34):5597-604.
Bhattacharya D, Umbleja T, Carrat F, Chung RT, Peters MG, Torriani F, Andersen J, Currier JS. Women experience higher rates of adverse events during hepatitis C virus therapy in HIV infection: a meta-analysis. J Acquir Immune Defic Syndr. 2010 Oct;55(2):170-5.
Sherman KE, Andersen JW, Butt AA, Umbleja T, Alston B, Koziel MJ, Peters MG, et al; for the AIDS Clinical Trials Group A5178 Study Team. Sustained Long-Term Antiviral Maintenance Therapy in HCV/HIV-Coinfected Patients (SLAM-C). J Acquir Immune Defic Syndr. 2010 Dec 15;55(5):597-605.
Tu Z, Li Q, Chou HS, Hsieh CC, Meyerson H, Peters MG, Bu H, Fung JJ, Qian S, Lu L, Lin F. Complement mediated hepatocytes injury in a model of autoantibody induced hepatitis.Immunobiology. 2011 Apr;216(4):528-34.
Kuniholm MH, Gao X, Xue X, Kovacs A, Marti D, Thio CL, Peters MG, et al. The relation of HLA genotype to hepatitis C viral load and markers of liver fibrosis in HIV-infected and HIV-uninfected women. J Infect Dis. 2011 Jun;203(12):1807-14.
Coffin CS, Mulrooney-Cousins PM, Peters MG, van Marle G, Roberts JP, Michalak TI, Terrault NA. Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy. J Viral Hepat. 2011 Jun;18(6):415-23.